It's recommended to install Manta into a virtual environment, instead of your system Python. Among the many other benefits virtual environments offer, this will conveniently add the `manta` executable to your PATH. This allows you to invoke the tool with `manta`, rather than the more verbose `python3 -m manta`.
The build system also uses the open-source `xc3sprog` and `iceprog` tools for programming Xilinx and ice40 devices, respectively. If you'd like to run these tests locally, you may need to install these tools and have them available on your `PATH`.
If you're on Linux, you may also need to add a new udev rule to give non-superuser accounts access to any connected FTDI devices. This can be done by making a new file at `/etc/udev/rules.d/99-ftdi-devices.rules`, which contains: