diff --git a/Makefile b/Makefile
index 03cae068..9b5078d6 100644
--- a/Makefile
+++ b/Makefile
@@ -139,9 +139,31 @@ $(foreach DB,$(DATABASES),$(eval $(call database,$(DB))))
 
 .PHONY: db-extras-artix7 db-extras-kintex7 db-extras-zynq7
 
+# Targets related to Project X-Ray parts
+# --------------------------------------
+
+ARTIX_PARTS=artix50t artix200t
+ZYNQ_PARTS=zynq020
+KINTEX_PARTS=kintex70t
+
+XRAY_PARTS=${ARTIX_PARTS} ${ZYNQ_PARTS} ${KINTEX_PARTS}
+
+define multiple-parts
+
+# $(1): PART to be used
+
+db-part-only-$(1):
+	+source settings/$(1).sh && $(MAKE) -C fuzzers part_only
+
+endef
+
+$(foreach PART,$(XRAY_PARTS),$(eval $(call multiple-parts,$(PART))))
+
+db-extras-artix7-parts: $(addprefix db-part-only-,$(ARTIX_PARTS))
+
 db-extras-artix7:
-	+source minitests/roi_harness/basys3-swbut.sh && $(MAKE) -C fuzzers part_only
-	+source minitests/roi_harness/arty-uart.sh && $(MAKE) -C fuzzers part_only
+	+source minitests/roi_harness/basys3-swbut.sh && $(MAKE) -C fuzzers roi_only
+	+source minitests/roi_harness/arty-uart.sh && $(MAKE) -C fuzzers roi_only
 	+source minitests/roi_harness/basys3-swbut.sh && \
 		$(MAKE) -C minitests/roi_harness \
 			HARNESS_DIR=$(XRAY_DATABASE_DIR)/artix7/harness/basys3/swbut run copy
@@ -158,6 +180,8 @@ db-extras-artix7:
 	+source minitests/roi_harness/arty-swbut.sh && \
 		$(MAKE) -C minitests/roi_harness \
 			HARNESS_DIR=$(XRAY_DATABASE_DIR)/artix7/harness/arty-a7/swbut run copy
+	# Generate multiple part support
+	+$(MAKE) db-extras-artix7-parts
 
 db-extras-kintex7:
 	@true
diff --git a/fuzzers/005-tilegrid/generate_tiles.tcl b/fuzzers/005-tilegrid/generate_tiles.tcl
index 64b62656..bdfb4304 100644
--- a/fuzzers/005-tilegrid/generate_tiles.tcl
+++ b/fuzzers/005-tilegrid/generate_tiles.tcl
@@ -3,6 +3,7 @@ source "$::env(FUZDIR)/util.tcl"
 proc write_tiles_txt {} {
     # Get all tiles, ie not just the selected LUTs
     set tiles [get_tiles]
+    set not_allowed_sites [get_sites -of_objects [get_pblocks exclude_roi]]
 
     # Write tiles.txt with site metadata
     set fp [open "tiles.txt" w]
@@ -12,6 +13,23 @@ proc write_tiles_txt {} {
         set grid_x [get_property GRID_POINT_X $tile]
         set grid_y [get_property GRID_POINT_Y $tile]
         set sites [get_sites -quiet -of_objects $tile]
+
+        # There are some sites which are not allowed to be placed.
+        # This check excludes tiles in the EXCLUDE_ROI pblock
+        # be added to tilegrid.json
+        set skip_tile 0
+        foreach site $sites {
+            set res [lsearch $not_allowed_sites $site]
+            if { $res != -1 } {
+                set skip_tile 1
+                break
+            }
+        }
+
+        if { $skip_tile == 1 } {
+            continue
+        }
+
         set typed_sites {}
 
         set clock_region "NA"
@@ -41,7 +59,7 @@ proc write_tiles_txt {} {
 
 proc run {} {
     # Generate grid of entire part
-    make_project_roi XRAY_ROI_TILEGRID
+    make_project_roi XRAY_ROI_TILEGRID XRAY_EXCLUDE_ROI_TILEGRID
 
     place_design
     route_design
diff --git a/fuzzers/005-tilegrid/util.tcl b/fuzzers/005-tilegrid/util.tcl
index dc9b511c..3765fff3 100644
--- a/fuzzers/005-tilegrid/util.tcl
+++ b/fuzzers/005-tilegrid/util.tcl
@@ -138,10 +138,10 @@ proc assign_iobs {} {
 
 proc make_project {} {
     # Generate .bit only over ROI
-    make_project_roi XRAY_ROI_TILEGRID
+    make_project_roi XRAY_ROI_TILEGRID XRAY_EXCLUDE_ROI_TILEGRID
 }
 
-proc make_project_roi { roi_var } {
+proc make_project_roi { roi_var exclude_roi_var } {
     # 6 CMTs in our reference part
     # What is the largest?
     set n_di 16
@@ -160,6 +160,13 @@ proc make_project_roi { roi_var } {
         resize_pblock [get_pblocks roi] -add "$roi"
     }
 
+    create_pblock exclude_roi
+    add_cells_to_pblock [get_pblocks roi] [get_cells roi]
+    foreach roi "$::env($exclude_roi_var)" {
+        puts "ROI: $roi"
+        resize_pblock [get_pblocks exclude_roi] -add "$roi"
+    }
+
     set_property CFGBVS VCCO [current_design]
     set_property CONFIG_VOLTAGE 3.3 [current_design]
     set_property BITSTREAM.GENERAL.PERFRAMECRC YES [current_design]
diff --git a/fuzzers/Makefile b/fuzzers/Makefile
index cea2fe41..1a1d4ac7 100644
--- a/fuzzers/Makefile
+++ b/fuzzers/Makefile
@@ -127,11 +127,46 @@ $(eval $(call fuzzer,100-dsp-mskpat,005-tilegrid))
 quick:
 	$(MAKE) QUICK=Y
 
-# part_only runs the fuzzers required for supporting additional parts.
-# Note: In theory this includes 005-tilegrid, but there isn't support for
-# multiple tilegrid's per family at this time.
-part_only:
+# roi_only runs the fuzzers required for supporting additional parts when building
+# an roi harness.
+roi_only:
 	+$(MAKE) -C 001-part-yaml run
 	+$(MAKE) -C 075-pins run
 
-.PHONY: all clean clean_fuzzers clean_logs quick part_only
+# Part only targets
+# -----------------
+
+part_only_yaml:
+	echo ${XRAY_FAMILY_DIR}/${XRAY_PART}/part.yaml
+	+$(MAKE) -C 001-part-yaml run
+	cp ${XRAY_FAMILY_DIR}/${XRAY_PART}.yaml ${XRAY_FAMILY_DIR}/${XRAY_PART}/part.yaml
+	cp ${XRAY_FAMILY_DIR}/${XRAY_PART}.json ${XRAY_FAMILY_DIR}/${XRAY_PART}/part.json
+
+part_only_tilegrid:
+	+$(MAKE) -C 005-tilegrid run
+	cp ${XRAY_FAMILY_DIR}/tilegrid.json ${XRAY_FAMILY_DIR}/${XRAY_PART}/tilegrid.json
+
+part_only_tileconn:
+	+$(MAKE) -C 072-ordered_wires run
+	+$(MAKE) -C 073-get_counts run
+	+$(MAKE) -C 074-dump_all run
+	cp ${XRAY_FAMILY_DIR}/tileconn.json ${XRAY_FAMILY_DIR}/${XRAY_PART}/tileconn.json
+
+part_only_pins:
+	+$(MAKE) -C 075-pins run
+	cp ${XRAY_FAMILY_DIR}/${XRAY_PART}_package_pins.csv ${XRAY_FAMILY_DIR}/${XRAY_PART}/package_pins.csv
+
+part_only:
+	# Create PART-specific directory
+	mkdir -p ${XRAY_FAMILY_DIR}/${XRAY_PART}
+	# Generate YAML
+	+$(MAKE) part_only_yaml
+	# Generate Tile grid
+	+$(MAKE) part_only_tilegrid
+	# Generate Tile connections
+	+$(MAKE) part_only_tileconn
+	# Generate package pins
+	+$(MAKE) part_only_pins
+
+
+.PHONY: all clean clean_fuzzers clean_logs quick part_only roi_only
diff --git a/settings/artix200t.sh b/settings/artix200t.sh
new file mode 100644
index 00000000..ea58e36d
--- /dev/null
+++ b/settings/artix200t.sh
@@ -0,0 +1,19 @@
+export XRAY_DATABASE="artix7"
+export XRAY_PART="xc7a200tffg1156-1"
+export XRAY_ROI_FRAMES="0x00000000:0xffffffff"
+
+# All CLB's in part, all BRAM's in part, all DSP's in part.
+# tcl queries IOB => don't bother adding
+export XRAY_ROI_TILEGRID="SLICE_X0Y0:SLICE_X163Y249 RAMB18_X0Y0:RAMB18_X8Y99 RAMB36_X0Y0:RAMB36_X8Y49 DSP48_X0Y0:DSP48_X8Y99 IOB_X0Y0:IOB_X1Y249"
+
+export XRAY_EXCLUDE_ROI_TILEGRID="SLICE_X82Y200:SLICE_X83Y249 SLICE_X82Y0:SLICE_X83Y49"
+
+export XRAY_PIN_00="R26"
+export XRAY_PIN_01="P26"
+export XRAY_PIN_02="N26"
+export XRAY_PIN_03="M27"
+export XRAY_PIN_04="U25"
+export XRAY_PIN_05="T25"
+export XRAY_PIN_06="P24"
+
+source $(dirname ${BASH_SOURCE[0]})/../utils/environment.sh
diff --git a/settings/artix50t.sh b/settings/artix50t.sh
new file mode 100644
index 00000000..726fb337
--- /dev/null
+++ b/settings/artix50t.sh
@@ -0,0 +1,19 @@
+export XRAY_DATABASE="artix7"
+export XRAY_PART="xc7a50tfgg484-1"
+export XRAY_ROI_FRAMES="0x00000000:0xffffffff"
+
+# All CLB's in part, all BRAM's in part, all DSP's in part.
+# tcl queries IOB => don't bother adding
+export XRAY_ROI_TILEGRID="SLICE_X0Y0:SLICE_X65Y99 SLICE_X0Y100:SLICE_X57Y149 RAMB18_X0Y0:RAMB18_X1Y59 RAMB36_X0Y0:RAMB36_X1Y29 RAMB18_X2Y0:RAMB18_X2Y39 RAMB36_X2Y0:RAMB36_X2Y19 DSP48_X0Y0:DSP48_X1Y59"
+
+export XRAY_EXCLUDE_ROI_TILEGRID=""
+
+export XRAY_PIN_00="E22"
+export XRAY_PIN_01="D22"
+export XRAY_PIN_02="E21"
+export XRAY_PIN_03="D21"
+export XRAY_PIN_04="G21"
+export XRAY_PIN_05="G22"
+export XRAY_PIN_06="F21"
+
+source $(dirname ${BASH_SOURCE[0]})/../utils/environment.sh
diff --git a/settings/artix7.sh b/settings/artix7.sh
index 7c8a9386..a6322781 100644
--- a/settings/artix7.sh
+++ b/settings/artix7.sh
@@ -6,6 +6,8 @@ export XRAY_ROI_FRAMES="0x00000000:0xffffffff"
 # tcl queries IOB => don't bother adding
 export XRAY_ROI_TILEGRID="SLICE_X0Y0:SLICE_X65Y99 SLICE_X0Y100:SLICE_X57Y149 RAMB18_X0Y0:RAMB18_X1Y59 RAMB36_X0Y0:RAMB36_X1Y29 RAMB18_X2Y0:RAMB18_X2Y39 RAMB36_X2Y0:RAMB36_X2Y19 DSP48_X0Y0:DSP48_X1Y59"
 
+export XRAY_EXCLUDE_ROI_TILEGRID=""
+
 # These settings must remain in sync
 export XRAY_ROI="SLICE_X0Y100:SLICE_X35Y149 RAMB18_X0Y40:RAMB18_X0Y59 RAMB36_X0Y20:RAMB36_X0Y29 DSP48_X0Y40:DSP48_X0Y59 IOB_X0Y100:IOB_X0Y149"
 # Most of CMT X0Y2.
diff --git a/settings/kintex7.sh b/settings/kintex7.sh
index acd366a3..a2a66ea0 100644
--- a/settings/kintex7.sh
+++ b/settings/kintex7.sh
@@ -5,6 +5,8 @@ export XRAY_ROI_FRAMES="0x00000000:0xffffffff"
 # FIXME: make entire part
 export XRAY_ROI_TILEGRID="SLICE_X0Y50:SLICE_X19Y99 DSP48_X0Y20:DSP48_X0Y39 RAMB18_X0Y20:RAMB18_X0Y39 RAMB36_X0Y10:RAMB36_X0Y19"
 
+export XRAY_EXCLUDE_ROI_TILEGRID=""
+
 # These settings must remain in sync
 export XRAY_ROI="SLICE_X0Y50:SLICE_X19Y99 DSP48_X0Y20:DSP48_X0Y39 RAMB18_X0Y20:RAMB18_X0Y39 RAMB36_X0Y10:RAMB36_X0Y19 IOB_X0Y50:IOB_X0Y99"
 # Part of CMT X0Y1
diff --git a/settings/zynq7.sh b/settings/zynq7.sh
index 64c75b87..97a9b826 100644
--- a/settings/zynq7.sh
+++ b/settings/zynq7.sh
@@ -5,6 +5,8 @@ export XRAY_ROI_FRAMES="0x00000000:0xffffffff"
 # All CLB's in part, all BRAM's in part, all DSP's in part.
 export XRAY_ROI_TILEGRID="SLICE_X0Y0:SLICE_X43Y99 RAMB18_X0Y0:RAMB18_X2Y39 RAMB36_X0Y0:RAMB36_X2Y19 DSP48_X0Y0:DSP48_X1Y39"
 
+export XRAY_EXCLUDE_ROI_TILEGRID=""
+
 # These settings must remain in sync
 export XRAY_ROI="SLICE_X00Y50:SLICE_X43Y99 RAMB18_X0Y20:RAMB18_X2Y39 RAMB36_X0Y10:RAMB36_X2Y19 IOB_X0Y50:IOB_X0Y99"
 
diff --git a/utils/environment.sh b/utils/environment.sh
index 90b328b7..3158ad03 100644
--- a/utils/environment.sh
+++ b/utils/environment.sh
@@ -10,6 +10,7 @@ export XRAY_DIR="$( dirname "$XRAY_UTILS_DIR" )"
 export XRAY_DATABASE_DIR="${XRAY_DIR}/database"
 export XRAY_TOOLS_DIR="${XRAY_DIR}/build/tools"
 export XRAY_FUZZERS_DIR="${XRAY_DIR}/fuzzers"
+export XRAY_FAMILY_DIR="${XRAY_DATABASE_DIR}/${XRAY_DATABASE}"
 
 if [ -e "${XRAY_DIR}/env/bin/activate" ]; then
   source "${XRAY_DIR}/env/bin/activate"